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A retrospective study was conducted in 144 septic shock patients in a 30-bed mixed ICU. A Pv-aCO 2/Ca-vO 2 ratio > 1.4 was considered abnormal. Patients were classified into four predefined groups according to lactate levels and Pv-aCO 2/Ca-vO 2 ratio after the first 6 h of resuscitation. Sequential Organ Failure Assessment (SOFA) score at day 3 was assessed. A Kaplan-Meier curve showed the survival probabilities at day 28 using a log-rank test to evaluate the differences between groups. A receiver operating characteristics (ROC) curve evaluated the ability of lactate, Pv-aCO 2/Ca-vO 2 ratio and Pv-aCO 2/Ca-vO 2 ratio combined with lactate to predict mortality at day 28.. This was a 12-week prospective observational study where vildagliptin 50 mg twice daily was added to patients with T2DM inadequately controlled (glycosylated hemoglobin type A1c (Hba1c) 7–10%) by a daily dose of metformin ≥1700 mg between June 2012 and May 2013. Efficacy was assessed by change in Hba1c and fasting plasma glucose (FPG) levels, and safety was assessed by reported adverse events (AEs).
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