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A retrospective study was conducted in 144 septic shock patients in a 30-bed mixed ICU. A Pv-aCO 2/Ca-vO 2 ratio > 1.4 was considered abnormal. Patients were classified into four predefined groups according to lactate levels and Pv-aCO 2/Ca-vO 2 ratio after the first 6 h of resuscitation. Sequential Organ Failure Assessment (SOFA) score at day 3 was assessed. A Kaplan-Meier curve showed the survival probabilities at day 28 using a log-rank test to evaluate the differences between groups. A receiver operating characteristics (ROC) curve evaluated the ability of lactate, Pv-aCO 2/Ca-vO 2 ratio and Pv-aCO 2/Ca-vO 2 ratio combined with lactate to predict mortality at day 28.. This was a 12-week prospective observational study where vildagliptin 50 mg twice daily was added to patients with T2DM inadequately controlled (glycosylated hemoglobin type A1c (Hba1c) 7–10%) by a daily dose of metformin ≥1700 mg between June 2012 and May 2013. Efficacy was assessed by change in Hba1c and fasting plasma glucose (FPG) levels, and safety was assessed by reported adverse events (AEs).

This was a 12-week prospective observational study where vildagliptin 50 mg twice daily was added to patients with T2DM inadequately controlled (glycosylated hemoglobin type A1c (Hba1c) 7–10%) by a daily dose of metformin ≥1700 mg between June 2012 and May 2013. Efficacy was assessed by change in Hba1c and fasting plasma glucose (FPG) levels, and safety was assessed by reported adverse events (AEs).. Spacers could be indicated in the treatment of proximal femur infections. Beyond the infection eradication a pain reduction is possible due to the spacer implantation. The mobility of the patients between stages could be enhanced by improving the spacer's mechanical properties.

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