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Transplantation of livers from donors with isolated anti-HBc-positivity (i.e. negative for HBsAg and anti-HBs) has resulted in additional challenges, since isolated anti-HBc-positive livers are capable of transferring HBV infection to 50-78% of HBV-naïve recipients in the absence of preventative therapy [20,21]. In addition, HBV-naïve recipients who have not been vaccinated to prevent hepatitis B prior to OLT have an ongoing risk of acquiring parenterally transmitted HBV infections that require prompt diagnosis and treatment [22-24]. Mandatory hepatitis B vaccination for all HBV-naïve patients with diseases that could require OLT could significantly reduce this risk..
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