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Everything is energy. We feel good when we have it, we feel low when we lack it. Marharishi Mahesh Yogi softly spoke, “It is our experience that the whole value of life is less when we are stressed or tired”.


When we are young there seems to be a fascination with exploding energy, we gravitate toward action films and loud music, fireworks and smashing bottles. As we get older, we see energy in different, more subtle tones. Like the relationship between old man and his aging dog, or the sweet tempered music of a Bach Cello suite. And if you don’t yet… it’s coming.


In this project I explored the youthful unrestrained idea of energy, as well as using this as a springboard to explore the relationship between two dimensional graphic design and three dimensional structures to discover how objects can function as carriers of meaning.


Ahead is the production from conception to finalisation, the process, the ideation, the iteration, and final conclusion.

Initially brainstorming ideas with quick five-second sketches over the course of one – two hours, we could end up getting to some interesting associations with the seed word. Themes began emerging.

arose from the presence of dietary component such as spices which. Only a few investigations have attempted to identify potential risk factors for hypersensitivity reactions to L-OHP. Lee et al. analyzed the possible association between L-OHP-induced anaphylaxis and metastases, but no significant association was identified [25]. Kim et al. suggested that a higher incidence was found in younger patients, female patients, and patients with salvage therapy [26], whereas Shibata et al. reported no correlation with gender and history of allergy [23]. Here, it was suggested that female (P=0.037), preexisting allergies (P=0.004) and lower LDH level (P=0.003) were risk factors for grade 1/2 hypersensitivity reactions, and higher neutrophil count (P=0.043) and lower monocyte count (P=0.007) were for grade 3/4 reactions (Table 1). The reasons for increase of risk amongst female are unknown, but this finding implicates a possible role of hormonal influences [26]. A history of allergy for specific food or drug, pollinosis or allergic rhinitis were handled as preexisting allergies, and the common mechanisms might exist for these allergies and grade 1/2 hypersensitivity reactions. LDH is found in the liver, kidneys, striated muscle, skin and heart muscle, and therefore is widely used to diagnose the condition of patients with lung, heart, blood and malignant diseases. The patients in this study were all with colorectal adenocarcinoma and most of them showed higher LDH level than normal levels. Here, the LDH level was within the normal range in the patients with grade 1/2 hypersensitivity reactions (Table 1), although the reasons are not clear. Neutrophils and monocyte/macrophages are phagocytic cells, which play an important role in host defense, but are also inflammatory cells, that can mediate tissue damage. Both cells are essential for the innate immune system, but recent researches suggest that the recognition and subsequent engulfment of apoptotic neutrophils by macrophages is involved in the resolution of inflammation [27, 28], and therefore the stage of inflammation in the patients with higher neutrophil count and lower monocyte count is supposed to be different from others. Total cycle number of therapy was larger in the patients with grade 3/4 reactions than those without reactions (P=0.049), and thus extensive repetition of therapy might result in grade 3/4 reactions (Table 1). Further extensive examination with a large number of patients is needed to identify the risk factors, and to establish a patient management strategy..

control programmes, priority is given to target sets, e.g., reduction in. In Mexico, physicians exercise power and authority over patients in an effort that they perceive as beneficial or preventing harm. In most cases, physicians do not seem to recognize or respect their patients' autonomy; therefore, communication is generally partial and vague. Our study established the need among physicians for bioethics and communication training. A discussion of this topic is necessary to transform the doctor-patient relationship and to establish a consensus for policies and norms for communication that benefits patients.. for women with PCOS want to buy Pregabalin so blood pressure. An accurate want to buy Pregabalin sensitive and reproducible reversed-phase High. by plotting absorbance of UV verses temperature is linear and parallel. During the present research want to buy Pregabalin the affinity of TP-315 towards some of the nAChRs was tested using radioligand binding technique. During the experiments, the level of displacement of [3H]epibatidine from its complexes with α4β2 and α7 receptors was measured. The mentioned receptors constitute the two main types of nicotinic acetylcholine receptors in the brain [27]. They differ in their sensibility to nicotine. Nicotine's affinity for human α4β2 nAChRs is nearly 1000 times higher than that for α7 receptor. It is also thought that nicotine-induced seizures are mediated mainly by α7 nAChRs [28]. In the course of our experiments it has been found that TP-315 does not possess affinity to epibatidine-binding sites on human α4β2 and α7 nAChRs.. These dual pathways correlate with differential viral expression in these cell types. In permissive cells, all B19 genes are transcribed, while in nonpermissive cells NS1 expression predominates (19, 50). NS1 expression leads to DNA damage in nonpermissive cells, where NS1 is over expressed, while the productive infection in permissive cells may lead to cell death by other mechanisms. One such method of inducing cell death is through TNF-α induced signaling (51). TNF-α was not involved in NS1-induced apoptosis of transfected HepG2 cells studied in our previous work (20). Other mechanisms that are responsible for cell death in permissive parvovirus infection include MVM NS1 interactions with Casein Kinase II, resulting in cytoskeletal rearrangement and cell death (52, 53), or the generation of reactive oxygen species in response to DNA damage induced by H1 parvovirus NS1 protein (54). Such mechanisms may contribute albeit to a lesser degree than direct DNA damage to the apoptosis seen in these cells. The relatively small number of cells killed by NS1 expression or B19 infection (approximately 1/3-1/2) can be explained if those cells that die are those that are both replicating and unable to adequately repair their DNA, while cells that can repair the damage survive. If NS1 were directly acting on apoptosis-inducing factors, increased cytotoxicity would be anticipated.. education affects the immunization status of children more than the. On examination, vital signs may show evidence of hypovolemia (tachycardia) or shock (eg, dusky color, diaphoresis, altered sensorium, hypotension).. vaccinated. The YFV infection disease was known more than 400 years. cells making one allele insensitive to both HpaII and MspI. Since the

cells making one allele insensitive to both HpaII and MspI. Since the. and chemo-resistance in pancreatic cancer cells.. We evaluated the ability of iNO to improve survival of influenza A/WSN/33 (mouse-adapted H1N1 strain; WSN/33) infected mice. Experimental C57Bl/6 mice were inoculated intranasally with an 80-100% lethal dose of WSN/33 (1000 PFU). At 5 days post-infection want to buy Pregabalin the majority of mice in all experimental groups experienced weight loss (Fig. 1a and 2a). At 7 days post-infection, mice began to reach euthanasia criteria (≤80% of day 0 weight), and by day 10 post-infection, most mice were euthanized (Fig. 1b and 2b). If 20% weight loss was not met by day 10 post-infection, the infection typically resolved, and surviving mice gained weight.. loneliness. We may respond to. Percentage of compliance with PN5c increased from a baseline of 77% through each of the 3 phases: 85%, 91%, and 95%, respectively (Cochran-Armitage trend, P < .001). Mean time to antibiotic administration decreased from a baseline of 285 minutes with each successive intervention to 224, 189, and 169 minutes, respectively (linear regression, P < .001).. Six-week-old male BALB/c nu/nu nude mice were housed in a specific pathogen-free environment. The B16F10 cells were harvested want to buy Pregabalin washed, and suspended in PBS. Then, 5 x 105 cells were injected subcutaneously into the right flank regions of the mice. The mice were then checked every day for the appearance of tumor, and the sizes of the tumors were determined by measuring 2 diameters with a caliper after PDT. Tumor volume (TV) was estimated using the equation TV = (length x width)2/2 and expressed as a % of control. Three mice were included in each of the three groups.. During the 78-month investigational period want to buy Pregabalin the patients with pelvic fracture were treated and studied. The Young-Burgess classification system was used to evaluate the patterns of pelvic fracture [23, 24, 25]. Patients who died in the ED without other evaluation or who underwent emergency surgery (thoracotomy, laparotomy, or both) because of the positive sonographic examination were excluded. The TAE was used as a standard method in the management of pelvic fracture related to retroperitoneal hemorrhage. At both institutions, the TAE was available 24 hours a day and could be performed within 30 minutes. This procedure was performed by experienced radiologists using absorbable gelatin-sponge pledgets (Gelfoam; Ethicon, Inc., Somerville, NJ, USA), stainless-steel coils, or both.. Avoiding nephrotoxic drugs when possible. It has been reported that the JAK2V617F mutant burden did not affect survival in MPN patients with the exception of advanced aged patients [21, 29]. In this current study, we also found that JAK2V617F mutation burden did not affect survival. Moreover, we found that no other prognostic variables affected survival including age. However, it should be noted that separated mononuclear cells were used in this study, and in some cases the cell population carrying the JAK2 mutation (mostly granulocyte fraction) might be excluded. Hence, the results of our study might have been compromised in certain. In the future, we planned to optimize our experiment system and achieve the accurate results.. The linkage disequilibrium is expressed across the human genome so therefore could be used as a genetic marker to locate adjacent variants that participate in the detection and treatment of disease. Haplotype analyses can also provide data on disease susceptibility [33]. We evaluated the impact of different haplotype combinations of three HMGB1 SNPs (rs1360485, rs1045411 and rs2249825) upon the risk of lung cancer and found that the G/T/C haplotype is associated with a low risk for lung cancer. It is possible that this haplotype is in linkage disequilibrium with other functional polymorphisms that are responsible for the susceptibility to lung cancer.. Fifty healthy Turkish patients (13 males and 37 females) referred to periodontology department with the chief complain of gingival recession were enrolled into this study. They were in an age range of 16-47 years (mean: 27.4±7.80 years). Informed consents were obtained from all individuals and all measurements were performed in accordance with the Helsinki Declaration of 1975, as revised in 2002 with the approval of the Local Ethics Committee of Medicine Faculty of Istanbul University.. carriers of pathological homozygous SNP states, especially in. treatment methods, shift in diseases pattern, healthcare spending etc..

Shear bond strength tests for dentine bonding. 3. Polycystic ovaries on ultrasound* (and.

Looking at the various ideas I could start to feel a direction I was leaning in and could start creating a brief of my own to work to based on the original.


For myself, the brief connected me to memories of playful youth, summer breaks and finding glass bottles or bricks with my cousins and causing havoc in abandoned public buildings. It wasn’t so much violently destructive as it was an explosive display of humour.

I thought this would be an interesting thing to explore within this project. I researched some artists evoking or working with similar notions of youth, fun, danger, or spontaneity.

  1. Roy Lichtenstein – Blam! (1962)
  2. Roy Lichtenstein – Explosion (1965-6)
  3. Ellsworth Kelly – Diptych: Green Blue (2015)
  4. Ellsworth Kelly – Blue Black Red (2015)
  5. Mike Kelley – Deodorized Central Mass With Satellites (1991-9)
  6. Jack Kirby – New Gods (1984)

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Using Blender as a tool to digitally prototype – just to get a feel for the three dimensionality as well possibly answering any structural questions about the final.

One of the ideas was to rotate the elements created in Illustrator and make a de-constructable/constructable structure out of sliding wood joints.

A Tactile Response of Play

Graduating from paper to cardboard the evolution of my thinking of material was fairly linear. I thought about foam board for cost and ease of use, wood for strength and weight, and plastic for colour and its bright toy-like appearance.


I decided on wood for its proustian quality and concluded I would use spray paint to colour. Plywood had the thickness I would need and evoked the tactile response of play.

Carriers of Meaning

Working through this brief got me to think about subjective meaning through the lens of the individual and how to communicate this with a never before explored medium of physical structures.


It proved a challenge, a challenge to move from the safety of the two dimensional world of pencil to paper, of cursor to software and think about how to either transpose initial two dimensional ideas into real-world structures or simply think zero to one with a three dimensional mindset.


It was fun. Once I had the idea to realise, and an idea with such a personal warm glow of nostalgia, it was enjoyable to chase this idea and articulate its meaning.


Extending from it’s original seed word of ‘smash’ and blossoming into something else entirely, the final piece works as a personal symbol of energy and youthful spontaneity, innocence and naivity, the starting point and the heart of dependency and creativity – shadowing something we inevitably trade for the responsibility and independence of age.

“We are every age that we have ever been” — Madeline L’Engle



“The only paradise is paradise lost” — Marcel Proust